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Open Access Research article

Decreased risk of secondary brain herniation with intracranial pressure monitoring in patients with haemorrhagic stroke

Jingsong Zeng, Ping Zheng, Wusong Tong and Weimin Fang*

Author Affiliations

Department of Neurosurgery, Shanghai Pudong New area People’s Hospital, 490 South Chuanhuan Road, Shanghai, China

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BMC Anesthesiology 2014, 14:19  doi:10.1186/1471-2253-14-19

Published: 21 March 2014

Abstract

Background

Intracranial-pressure (ICP) monitoring is considered standard care for severe traumatic brain injury and is used frequently, but the efficacy of treatment based on monitoring in patients with hemorrhagic stroke has not been rigorously assessed. In this study, we investigated the clinical value of ICP monitoring in patients with hemorrhagic stroke.

Methods

We conducted a randomized, unblinded, controlled trial in which 90 patients with hemorrhagic stroke were randomly assigned to ICP monitoring or a control group. The primary outcome was a composite of incidence rate of hematoma enlargement and secondary brain herniation. The secondary outcome was neurological status assessed using the Glasgow Outcome Scale scores at 6 months post-onset. Characteristics of the patients at baseline and outcome measurements were also compared between the two groups.

Results

There was no significant between-group difference in the incidence of hematoma enlargement (control group, 38.6% vs. ICP monitoring group, 32.6%; P > 0.05). The incidence rate of secondary brain herniation in the ICP monitoring group was significantly lower compared with the control group (10.9% vs. 20.5%, P = 0.04). Six-month mortality was 6.5% in the ICP group and 9.1% in the control group (P < 0.05), and neurological outcome was better in the ICP group compared with the control group (P < 0.05).

Conclusion

The dynamic ICP value may be more sensitive and effective in preventing secondary brain herniation in patients with hemorrhagic stroke compared with guidance directed by clinical signs and radiological indicators.

Keywords:
Intracranial-pressure monitoring; Hematoma enlargement; Brain herniation; Hemorrhagic stroke