Table 1 |
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Steady-state rate of infusion of cisatracurium controlled by closed-loop feedback system to maintain neuromuscular blockade constant at 90% during total intravenous anesthesia (TIVA) with air (Air/TIVA) or with nitrous oxide (Nitrous oxide/TIVA). |
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Patients |
Controller performance |
Time to 10% recovery of T1 following the initial bolus (min) |
Cumulative dose of cisatracurium/IBW (mg/kg) |
Steady-state rate of infusion of cisatracurium |
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Group |
No. (M/F) |
ASA (1/2/3) |
Age (yr) |
Weight (kg) |
Height (cm) |
Offset from set-point (%) |
SD from set-point (%) |
Iss (mg/h) |
Iss/IBW (mg·kg-1·h-1) |
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Air/TIVA |
35 (20/15) |
23/12/0 |
47.3 ± 12.6 |
75.0 ± 14.3 |
173 ± 11 |
0.96 ± 1.25 |
3.03 ± 1.34 |
31.5 ± 6.1 |
12.4 ± 2.6 |
4.8 ± 1.5 |
0.072 ± 0.018 |
|
Nitrous oxide/TIVA |
35 (22/13) |
18/16/1 |
48.6 ± 12.3 |
77.7 ± 15.1 |
174 ± 10 |
1.10 ± 1.28 |
2.95 ± 1.19 |
34.4 ± 7.6 |
12.1 ± 2.2 |
4.5 ± 1.2 |
0.066 ± 0.017 |
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Mean difference (95% CI) |
1.3 (-4.7, 7.2) |
2.7 (-4.3, 9.7) |
1.3 (-3.8, 6.3) |
0.14 (-0.47, 0.74) |
-0.08 (-0.68, 0.53) |
2.9 (-0.4, 6.2) |
0.3 (-1.5, 0.8) |
-0.3 (-1.0, 0.3) |
-0.005 (-0.014, 0.003) |
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Values are mean ± SD. There were no statistically significant differences between the groups. ASA = American Society of Anesthesiologists physical status classification; CI = confidence interval of the difference in mean values; IBW = ideal body weight; Iss = asymptotic steady-state rate of infusion; Iss/IBW = asymptotic steady-state rate of infusion per kg ideal body weight; NMB = neuromuscular blockade; SD = standard deviation; T1 = first twitch in the train-of-four sequence. |
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Illman et al. BMC Anesthesiology 2010 10:14 doi:10.1186/1471-2253-10-14 |
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