Table 4 |
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|
Pharmacodynamic parameters |
|||
|
Parameter |
Typical Value |
95% Confidence Interval |
CV% |
|
|
|||
|
E0 |
0.158 |
-0.02 - 0.336 |
114 |
|
Emax |
17.8 |
15.6 - 19.9 |
93.3 |
|
EC50 ng/mL |
7580 |
6699 - 8461 |
22.2 |
|
Gamma |
6.28 |
5.03 - 7.53 |
35.6 |
|
Ke0(min-1) |
0.808 |
0.746 - 0.870 |
12.6 |
|
Ke0 half life (min) |
0.858 |
0.797 - 0.929 |
|
|
Residual error |
1.98 |
1.55 - 2.34 |
|
|
|
|||
|
Confidence intervals were calculated as the typical parameter (geometric mean) estimate ± 1.96 x standard error of the estimate. The coefficient of variation (CV%) was calculated, where possible, as the square root of the variance of the eta variable associated with that parameter. |
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|
Rigby-Jones et al. BMC Anesthesiology 2010 10:10 doi:10.1186/1471-2253-10-10 |
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