Table 4

Activation of muscarinic M₁ receptors by analogues of AC-260584 as measured by R-SAT

M₁ Agonist RSAT

pEC₅₀

%Efficacy

AC-260515

6.6 ± 0.2

66 ± 16

AC-262469

7.2 ± 0

107 ± 16

AC-260977

7.7 ± 0.1

107 ± 10

Activities of AC-260584 analogues on human M₁ receptors were assessed using R-SAT in transiently transfected NIH-3T3 cells. Data presented are mean ± SD from 5-7 independent experiments carried out in triplicate.

Davis et al. BMC Pharmacology 2009 9:14   doi:10.1186/1471-2210-9-14