|
Effect of CsA and sulphated polysaccharides on hepatic marker enzymes |
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| Enzyme parameters |
Group I (Control) |
Group II (CsA) |
Group III (Sulphated polysaccharides) |
Group IV (CsA + sulphated polysaccharides) |
|
|
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| AST |
0.22 ± 0.02 |
0.14 ± 0.01 a*** |
0.23 ± 0.03 |
0.19 ± 0.02 a*b*** |
| ALT |
0.18 ± 0.02 |
0.09 ± 0.01 a*** |
0.17 ± 0.02 |
0.15 ± 0.02 a*b*** |
| LDH |
11.57 ± 1.40 |
6.83 ± 0.75 a*** |
11.52 ± 1.13 |
10.22 ± 1.23 b*** |
| ALP |
1.58 ± 0.19 |
1.25 ± 0.15 a** |
1.60 ± 0.19 |
1.54 ± 0.15 b** |
|
Values are expressed as mean ± S.D. for six animals in each group. Units: AST, ALT – μmoles × 10-2 of pyruvate liberated/min/mg protein; LDH – μmoles × 10-1 of pyruvate liberated/min/mg protein; ALP – μmoles × 10-2 of phenol liberated/min/mg protein. Comparisons are made between: a – Group I and Groups II, III, IV; b – Group II and Group IV. The symbols (***), (**) and (*) represent statistical significance at P < 0.001, P < 0.01 and P < 0.05, respectively. | ||||
Josephine et al. BMC Pharmacology 2008 8:4 doi:10.1186/1471-2210-8-4 |
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