Table 9 |
||
|
Ki ratio values (Ki-D1/Ki-D2 and Ki-D2/Ki-5HT2A) of all test compounds except LE401 |
||
|
Compound |
Ki-D1/Ki-D2 |
Ki-D2/Ki-5HT2A |
|
|
||
|
Haloperidol |
102 (100a)) |
0.02 (0.05a)) |
|
|
||
|
Clozapine |
0.83 (1.58a)) |
42.6 (19.95a)) |
|
LE400 |
2.09 |
9.12 |
|
LE410 |
0.60 |
7.24 |
|
LE420 |
0.56 |
21.4 |
|
LE300 |
0.16 |
294 |
|
|
||
|
LE403 |
0.03 |
93.5 |
|
LE404 |
0.04 |
49.0 |
|
RMI-81582 |
0.05a) |
31.6a) |
|
|
||
|
SCH23390 |
0.0004b) |
50.0c) |
|
|
||
|
a) Value is calculated from [6]. b) Value is calculated from [33,34]. c) Value is calculated from [34,35]. Further, data for SCH23390 and RMI-81582 are calculated from literature data. Ki values used are derived from radioligand binding studies. |
||
|
Hamacher et al. BMC Pharmacology 2006 6:11 doi:10.1186/1471-2210-6-11 |
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