Figure 9.

Whole cell voltage-activated K⁺ currents in cultured DRG neurones are significantly reduced by c.Sg or c.Lobo (100 μg/mL). A) Line graph showing mean (± sem) current-voltage relationships under control conditions (blue line) and after the application of c.Sg (red and green lines). The current amplitudes measured at the peak (red) and at the end of the voltage step command (green) are illustrated. B) Net K⁺ current traces showing the onset of the inhibitory effects of c.Sg and the time course of partial recovery. The neurone was voltage clamped at -70 mV and currents were evoked by voltage step commands to +60 mV. C) Bar chart illustrating mean current amplitudes (n = 6; *P < 0.02) at +60 mV, under control conditions (blue bar), the peak current in the presence of c.Lobo (red bar) and the current recorded at the end of a 100 ms voltage step command in the presence of c.Lobo (yellow bar). D) Net K⁺ current traces showing the development of current inhibition by c.Lobo. The neurone was voltage clamped at -70 mV and currents were evoked by voltage step commands to +60 mV.