Additional File 1:

Differences in serum protein profiles between diabetic and wild-type mice Typical data of relative peak intensities in +m/+m and db+/db+ mouse sera (left 2 panels, representative of 4–8 independent observations) and the peak intensity averages at m/z indicated (right panels; +m/+m: open column, n = 4; db+/db+: closed column, n = 8). The analyzed peak is indicated by arrows in the data of mass spectral signals. **P < 0.01; significantly different from the peak in wild-type mice, by unpaired t-test. Types of ProteinChip used were described in the Fig. 6 legend.

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Additional File 2:

Changes in serum protein profiles of db+/db+ mice after green tea administration MS spectra shows typical changes in the serum protein profiles of db+/db+ mice administered with saline (left) or green tea (right). Graph shows the peak intensity averages at m/z indicated, before (open column) and after (closed column) administration with saline (n = 4) or green tea (n = 4). The analyzed peak is indicated by arrows in the MS spectra. **P < 0.01; significantly different from the peak obtained before the administration, by unpaired t-test. Types of ProteinChip used were described in the Fig. 7 legend.

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