Table 1

Effect of the PDE inhibitors on the activity of PDE3 and PDE4. Data are presented as means ± S.E.M except in the case PDE3 where a satisfactory IC₅₀ for 3 of the compounds could not be calculated.

PDE inhibitor

PDE3

PDE4

EMD95833

33% inhibition at 3 μM

IC₅₀ = 0.1 ± 0.004 μM

EMD219906

IC₅₀ = 1.3 ± 0.06 μM

IC₅₀ = 0.48 ± 0.03 μM

EMD249615

39% inhibition at 3 μM

IC₅₀ = 0.074 ± 0.004 μM

EMD273316

46% inhibition at 3 μM

IC₅₀ = 0.33 ± 0.01 μM

Scutt et al. BMC Pharmacology 2004 4:10   doi:10.1186/1471-2210-4-10