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Effect of nimesulide (NIM) on total sulfhydryl groups (TSH) and non-protein sulfhydryl groups (NPSH) following 20 min incubation with 12 mM kainic acid (KA). |
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| TSH (nmol/mg protein) |
NPSH (μmol/g tissue) |
|
|
|
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| Control |
23.97 ± 0.25 ** |
1.85 ± 0.03 ** |
| KA |
19.25 ± 0.35 |
1.61 ± 0.04 |
| KA + NIM (0.1 mM) |
18.72 ± 0.38 |
1.57 ± 0.03 |
| KA + NIM (0.2 mM) |
20.21 ± 0.56 |
1.64 ± 0.03 |
| KA + NIM (0.4 mM) |
20.25 ± 0.35 |
1.71 ± 0.02 |
| KA + NIM (0.6 mM) |
21.96 ± 0.46 * |
1.76 ± 0.03 * |
| KA + NIM (0.8 mM) |
22.67 ± 0.30 ** |
1.76 ± 0.01 * |
| KA + NIM (1.0 mM) |
23.14 ± 0.15 ** |
1.78 ± 0.02 * |
| KA + NIM (1.2 mM) |
23.03 ± 0.30 ** |
1.81 ± 0.04 ** |
| KA + NIM (1.4 mM) |
23.68 ± 0.25 ** |
1.79 ± 0.03 ** |
| KA + NIM (1.6 mM) |
24.03 ± 0.31 ** |
1.81 ± 0.02 ** |
|
Values are means ± SEM of 3 experiments. Significant differences were determined by one-way ANOVA followed by Student-Newman-Keuls post-hoc test: *P < 0.05 and **P < 0.01 with respect to KA 12 mM. | ||
Candelario-Jalil and Sonia León BMC Pharmacology 2003 3:7 doi:10.1186/1471-2210-3-7 |
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