Table 1 |
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|
Antileishmanial activity of diterpenes (1–4) and AMB. LD50 values in μg/ml obtained from a minimum of three separate experiments are shown. |
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|
Drugs |
L. aethiopica |
THP-1 |
|
|
promastigotes |
amastigotes |
||
|
|
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|
AMB |
0.189 ± 0.01 (n = 3) |
0.183 ± 0.04 (n = 6) |
>10 |
|
1 |
> 100 |
4.12 ± 0.28 (n = 5) |
>100 |
|
2 |
11.67 ± 0.88 (n = 3) |
1.08 ± 0.25 (n = 5) |
12.13 ± 1.42 (n = 4) |
|
3 |
> 100 |
19.2 ± 2.24 (n = 5) |
26 ± 3.89 (n = 4) |
|
4 |
18. 33 ± 1.05 (n = 3) |
4.52 ± 0.97 (n = 5) |
7 ± 1.08 (n = 4) |
|
|
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|
Habtemariam BMC Pharmacology 2003 3:6 doi:10.1186/1471-2210-3-6 |
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