Table 1

Antileishmanial activity of diterpenes (1–4) and AMB. LD50 values in μg/ml obtained from a minimum of three separate experiments are shown.

Drugs

L. aethiopica

THP-1

promastigotes

amastigotes


AMB

0.189 ± 0.01 (n = 3)

0.183 ± 0.04 (n = 6)

>10

1

> 100

4.12 ± 0.28 (n = 5)

>100

2

11.67 ± 0.88 (n = 3)

1.08 ± 0.25 (n = 5)

12.13 ± 1.42 (n = 4)

3

> 100

19.2 ± 2.24 (n = 5)

26 ± 3.89 (n = 4)

4

18. 33 ± 1.05 (n = 3)

4.52 ± 0.97 (n = 5)

7 ± 1.08 (n = 4)


Habtemariam BMC Pharmacology 2003 3:6   doi:10.1186/1471-2210-3-6

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