Direct activation of α1β2γ2 GABAA receptors by intravenous general anesthetics. (a) Bar histogram of the direct activation of GABAA receptor-mediated chloride currents by propofol, etomidate and alphaxalone. Data points represent means ± standard error, n = 9–19; *p < 0.05; Student's t-test). (b) Selected traces showing representative whole-cell chloride currents activated by propofol, etomidate and alphaxalone.
Siegwart et al. BMC Pharmacology 2003 3:13 doi:10.1186/1471-2210-3-13