A schematic depicting the potential roles of different oxidative enzymes in retinoic acid biosynthesis and the differentiation vs. self-renewal response to the retinoic acid ligand at different stages of hematopoiesis. Hematopoietic stem cell (HSC). All-trans retinal (Ral). All-trans retinoic acid (RA).
Russo et al. BMC Pharmacology 2002 2:4 doi:10.1186/1471-2210-2-4