Table 1

Effects of various NO donors on stimulation evoked [³H]noradrenaline release and vasoconstriction in the rat tail arteries

Treatment

n

S₄/S₂ ratio

[³H]noradrenaline

Vasoconstriction

Control

7

1.08 ± 0.05

1.04 ± 0.06

DNIC-cysteine 3 μM

6

1.31 ± 0.06^**

0.25 ± 0.02^**

DNIC-thiosulfate 3 μM

6

1.38 ± 0.07^**

0.33 ± 0.04^**

Fe(II)-thiosulfate 10 μM

6

1.01 ± 0.03

0.92 ± 0.05

SNP 10 μM

7

1.04 ± 0.04

0.27 ± 0.06^**

Cys-NO 10 μM

7

1.08 ± 0.06

0.23 ± 0.02^**

GS-NO 10 μM

7

1.01 ± 0.03

0.27 ± 0.02^**

^**P < 0.01 in comparison to control arteries.

Kleschyov et al. BMC Pharmacology 2002 2:3   doi:10.1186/1471-2210-2-3