Table 2

Skin permeation parameters

Formulation

Recovery (%)

Jmax (μ g/cm2/h)

Lagtime (h)

Skin absorption (μ g/cm2)


Ibutop® gel

21 ± 5a

50 ± 23

0.0 ± 0.2ac

239 ± 159

Ibutop® cream

59 ± 8

65 ± 15

1.3 ± 0.6

57 ± 25

Ibuprofen solution

26 ± 8b

42 ± 16

1.3 ± 0.8

264 ± 192


Absorption parameters of bovine udder skin (recovery in the receptor chamber, Jmax, lagtime, and skin absorption) following application of different topical formulations containing ibuprofen 5%; n = 5-6, mean and standard deviation; p < 0.05 (One-way ANOVA followed by Tukey's multiple comparison test; a: gel vs. cream, b: solution vs. cream, c: gel vs. solution)

Stahl et al. BMC Pharmacology 2011 11:12   doi:10.1186/1471-2210-11-12

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