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Resolution: standard / high Figure 3.
A rational promiscuity approach to drug screening. Coverage maps are generated for individual drugs, here plotted as relative affinity
for targets A-J indicated by radial distance from the origin (in arbitrary units).
Combining the maps clearly illustrates that targets A-F are shared by all 3 drugs
(dotted line). Subsequent screening algorithms would enrich for targets A-F, while
avoiding non-shared targets G-J.
Bianchi and Botzolakis BMC Pharmacology 2010 10:3 doi:10.1186/1471-2210-10-3 |