Effect of CCl4 with or without prior administration of natansnin on SOD levels in liver homogenate and mitochondria. Superoxide dismutase levels were estimated in homogenate, mitochondrial fragment and pure mitochondria from control, CCl4 and natansnin (10 mg/kg, 20 mg/kg body weight) treated rats. Values are given as percent control, and are mean ± S.D. of at least four animals. 0.3 mg of homogenate protein and 0.1 mg protein of sample (mitochondrial fragment and mitochondria) were used for each assay. Super oxide dismutase activity is expressed as units per mg protein. The control values of super oxide dismutase of homogenate and mitochondrial fragment and intact mitochondria were 2.88 ± 0.19, 3.08 ± 0.21 and 4.73 ± 0.25 respectively. a = Statistical significant at P < 0.05 as compare to control, b = Statistical significant at P < 0.05 as compare to CCl4, c = Statistical significant at P < 0.05 as compare to CCl4+ natansnin (10 mg).
Srilaxmi et al. BMC Pharmacology 2010 10:13 doi:10.1186/1471-2210-10-13