Effect of CCl4 with or without prior administration of natansnin on lipid peroxide level in liver homogenate and mitochondria. Homogenate and mitochondrial fractions were isolated from control, CCl4 and natansnin (10 mg/kg, 20 mg/kg body weight) treated rats and lipid peroxides were estimated using thiobarbituric acid reaction method. Values are given as percent control, and are mean ± S.D. of at least four animals. Lipid peroxide levels were expressed as nmol MDA formed per 100 mg protein. The control values in homogenate and mitochondria are 135.2 ± 8.6, 121.4 ± 6.6 respectively. a = Statistical significant at P < 0.05 as compare to control, b = Statistical significant at P < 0.05 as compare to CCl4, c = Statistical significant at P < 0.05 as compare to CCl4+ natansnin (10 mg).
Srilaxmi et al. BMC Pharmacology 2010 10:13 doi:10.1186/1471-2210-10-13