Table 1 |
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|
Time elapsed (sec.) for nociceptive response in Hot Plate Test in mice related to the time of experiment. |
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|
Treatment |
Time elapsed after treatment (means ± SD)/ Increase in response time compared to control (%) |
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|
|
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|
N |
0 min |
30 min |
60 min |
90 min |
120 min |
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|
|
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|
Control |
7 |
3.4 ± 1.2 |
3.4 ± 1.5 |
NS |
5.2 ± 0.92 |
NS |
7.04 ± 0.75 |
NS |
6.0 ± 0.95 |
NS |
|
|
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|
Morphine 20 mg.kg-1 |
6 |
2.07 ± 0.65 |
6.9 ± 0.76 |
203%** |
8.15 ± 1.52 |
163.5%* |
13.35 ± 4.05 |
189.6%** |
6.8 ± 2.11 |
NS |
|
|
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|
Naloxone 1 mg.kg1/control |
6 |
3.0 ± 0.39 |
4.72 ± 0.77 |
NS |
5.3 ± 0.7 |
NS |
6.25 ± 1.23 |
NS |
6.65 ± 0.9 |
NS |
|
|
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|
Naloxone 1 mg.kg1/Morphine20 mg.kg1 |
8 |
3.6 ± 1.12 |
4.81 ± 1.42 |
NS |
7.07 ± 2.23 |
NS |
5.2 ± 1.53 |
NS |
6.0 ± 1.27 |
NS |
|
|
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|
C2 100 mg.kg-1 |
8 |
3.5 ± 1.0 |
4.88 ± 2.21 |
NS |
12.35 ± 1.24 |
237.5%** |
11.5 ± 2.77 |
163.4%** |
7.38 ± 0.76 |
NS |
|
|
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|
Naloxone1 mg.kg1/C2 100 mg.kg1 |
7 |
3.4 ± 1.2 |
4.21 ± 1.8 |
NS |
11.5 ± 2.11 |
221.2%** |
9.41 ± 2.69 |
NS |
6.65 ± 2.8 |
NS |
|
|
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|
C1 100 mg.kg-1 |
8 |
3.1 ± 1.2 |
6.16 ± 2.0 |
179%** |
10.66 ± 2.13 |
205%** |
8.98 ± 1.48 |
NS |
9.2 ± 2.4 |
153.3%** |
|
|
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|
Naloxone1 mg.kg1/C1 100 mg.kg1 |
8 |
3.5 ± 1.3 |
5.0 ± 1.68 |
NS |
13.42 ± 2.24 |
258%** |
12.06 ± 2.27 |
171.3%** |
6.7 ± 2.12 |
NS |
|
|
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|
Statistical Analysis ANOVA DUNCAN'S Test: *p < 0.05; **p < 0.01 NS: no significant result Morphine, Naloxone, C1, C2 and vehicle given orally. |
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|
Spindola et al. BMC Pharmacology 2010 10:1 doi:10.1186/1471-2210-10-1 |
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