|
Effects of cumulative doses of olanzapine on urodynamic and EMG parameters in anesthetized rats. Values are Mean ± S.E.M. |
||||||||||||
| Urodynamic parameters |
EUS EMG parameters |
|||||||||||
|
|
|
|||||||||||
| Dose |
BC (ml) |
MV (ml) |
RV (%) |
PT |
PP |
CT (sec) |
ET (sec) |
HFO |
Phase 1 |
Phase 2 |
Phase 3 |
Burst |
| (mg/kg) |
(mm Hg) |
(mm Hg) |
(mm Hg) |
(%) |
(%) |
(%) |
Amp. (%) |
|||||
|
|
||||||||||||
| Control |
0.28 |
0.20 |
26 |
4.1 |
14.3 |
16.8 |
2.6 |
1.6 |
100 |
100 |
100 |
100 |
| (±0.046) |
(±0.037) |
(±8.7) |
(±0.93) |
(±1.26) |
(±0.61) |
(±0.55) |
(±0.19) |
|||||
| 0.01 |
0.30 |
0.22 |
23 |
5.5 |
13.6 |
17.0 |
3.3 |
1.6 |
80 |
138 |
94 (±4.6) |
105 |
| (±0.049) |
(±0.045) |
(±10.8) |
(±0.96) |
(±0.90) |
(±1.57) |
(±0.63) |
(±0.17) |
(±14.0) |
(±23.4) |
(±3.2) |
||
| 0.1 |
0.39 |
0.08* |
76** |
4.9 |
14.6 |
17.1 |
0.9** |
1.0* |
76* |
42** |
69** |
72 |
| (±0.064) |
(±0.014) |
(±5.3) |
(±1.52) |
(±0.91) |
(±0.91) |
(±0.38) |
(±.42) |
(±1.9) |
(±11.4) |
(±12.6) |
(±19.2) |
|
| 1 |
0.38 |
0.04** |
89** |
6.84 |
12.7 |
17.38 |
0** |
0** |
47** |
0** |
35** |
0** |
| (±0.072) |
(±0.006) |
(±2.4) |
(±1.79) |
(±1.24) |
(±2.60) |
(±6.0) |
(±5.2) |
|||||
|
* p < 0.05; ** p < 0.01 | ||||||||||||
Vera et al. BMC Pharmacology 2001 1:4 doi:10.1186/1471-2210-1-4 |
||||||||||||