Table 1

Desired properties for drug candidate taken for evaluation in formal animal toxicity studies.

Properties

Details


Chemical properties

Stable molecule


Nonproblematic synthesis with potential for scale-up


Pharmacological properties

Selective high-affinity binding to target binding site


Selective and potent functional effect on target receptor molecule in vitro


Effectiveness in animal model of targeted human indication


Pharmacokinetics

Adequate bioavailability for selected route of administration


Adequate half-life and biodistribution for intended use


Safety and toxicity

Satisfactory profile for inhibition and induction of cytochrome P450 enzymes


Absence of obvious cardiac toxicity (hERG binding)


Absence of obvious toxicity in animal studies


Hefti BMC Neuroscience 2008 9(Suppl 3):S7   doi:10.1186/1471-2202-9-S3-S7

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