This article is part of the supplement: Proceedings of the 8th International Conference on Alzheimer's Disease Drug Discovery
Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
Max-Planck-Unit for Structural Molecular Biology, c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany
BMC Neuroscience 2008, 9(Suppl 2):S9 doi:10.1186/1471-2202-9-S2-S9Published: 3 December 2008
Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the activity of MARK and its pathways. Here we summarize structural features of MARK and cellular pathways of regulation.