Table 2

Summary of the effect of various drugs/compounds targeted to the IRE in the APP mRNA 5'UTR on holo-APP and Aβ levels

Drug/compound

Mechanism of action

Holo-APP levels

Aβ levels

Reference


M30

Novel multifunctional iron chelator

[51]

VK28

Novel multifunctional iron chelator

Unpublished data

HLA20

Novel multifunctional iron chelator

Unpublished data

EGCG

Main polyphenol constituent of green tea

[56]

FDA approved drugs

DFO

Prototype iron chelator

[25]

Paroxetine

SSRI and chelator

[47,65]

Dimercapropanol

Hg2+ and Pb2+ chelator

[47]

Phenserine

Anticholinesterase

[66]

Tetrathiomolybdate

Cu2+ chelator

[38]

Azithromycin

Macrolide antibiotic

[38]

Erythromycin

Macrolide antibiotic

[65]

N-acetyl cysteine

Antioxidant

[65]

XH-1

Bi-functional metal chelator

[48]


Arrows indicate decreased levels. SSRI, selective serotonin reuptake inhibitor.

Avramovich-Tirosh et al. BMC Neuroscience 2008 9(Suppl 2):S2   doi:10.1186/1471-2202-9-S2-S2

Open Data