Table 1

Summary of inhibitiory constants for angiotensin IV and LVV-hemorphin 7 and their analogues for IRAP

Reference

Ki (nM) *


Angiotensin IV and analogues

Val-Tyr-Ile-His-Pro-Phe

[21]

113

Nle-Tyr-Ile-His-Pro-Phe

[21]

340

Val-Tyr-Ile-Cys-Pro-Cys

[49]

25.8

Val-Tyr-Ile-[AMPAA]

[49]

43.6

Valψ(CH2NH2)-Tyr-Valψ(CH2NH2)-His-Pro-Phe (divalinal-AT4)

[21]

2300

β2hVal-Tyr-Ile-His-Pro-Phe

[51]

26

LVV-hemorphin 7 and analogues

Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe

[48]

196

Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe

[21]

845

Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe

[48]

56

Leu-Val-Val-Tyr-Pro-Trp-Thr

[48]

560

Val-Tyr-Pro-Trp-Thr

[48]

112

Val-Tyr-Pro

[48]

620


*Data obtained using HEK293 cells transiently transfected with insulin-regulated aminopeptidase and L-Leu-pNA as substrate. Comparative angiotensin IV Ki data not reported. Angiotensin IV Ki reported as 56 nM in this assay.

Chai et al. BMC Neuroscience 2008 9(Suppl 2):S14   doi:10.1186/1471-2202-9-S2-S14

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