Figure 6.

Edaravone-administration exerted neuroprotective effects in a dose-responsive manner immunohistochemically in vivo. Left graph: TH staining of the striatum demonstrates neuroprotective effects of edaravone on 6-OHDA-lesioned striatal DA fibers in a dose-responsive manner. Data are shown as the percentages of TH-positive fibers relative to the intact side ± S.E. *p < 0.05 vs. rats in all other groups, **p < 0.05 vs. rats receiving 30 mg/kg of edaravone and those without edaravone-administration, ***p < 0.05 vs. rats without edaravone-administration, ****p < 0.05 (rats receiving edaravone at 30 minutes after 6-OHDA lesion (30 min group) vs. rats with edaravone at 24 hours (24 h group)). Right graph: TH staining of the SNc demonstrates neuroprotective effects of edaravone on 6-OHDA-lesioned striatal DA fibers in a dose-responsive manner. Data are shown as the percentages of TH-positive neurons relative to the intact side ± S.E. *p < 0.05 vs. rats in all other groups, **p < 0.05 vs. rats receiving 30 mg/kg of edaravone and those without edaravone-administration.

Ji Yuan et al. BMC Neuroscience 2008 9:75   doi:10.1186/1471-2202-9-75
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