Reduced TUNEL-positive apoptotic 6-OHDA-treated DA neurons with edaravone-administration in vitro. Upper column: TUNEL-positive 6-OHDA-treated DA neurons with 10-3 M edaravone (b) significantly decreased, compared to those without edaravone-administration (a). Scale bar: 60 μm. Lower column: The graph demonstrates that TUNEL-positive 6-OHDA-treated DA neurons decreased by 10-4 and 10-3 M edaravone-administration. Data are shown as mean percentages of the cell number relative to the 6-OHDA-treated DA neurons without edaravone-administration +S.E. *p < 0.01 vs. 6-OHDA-treated DA neurons without edaravone-administration and those with low dose edaravone (10-6 and 10-5 M) by ANOVA. **p < 0.01 vs. 6-OHDA-treated DA neurons without edaravone-administration.
Ji Yuan et al. BMC Neuroscience 2008 9:75 doi:10.1186/1471-2202-9-75