Additional file 4.

TS2/16 does activate integrin beta 1 signalling. (A) Platelet adhesion assay, demonstrating that the activating-β1 integrin antibody, TS2/16, stimulates adhesion to pepsin-digested collagen I at the concentrations of 5 μg/ml, relative to medium alone or to an isotype control antibody. (B) Western blot showing that 10 μg/ml TS2/16 stimulates focal adhesion kinase (FAK) phosphorylation on tyrosine 397 (pY397) after 10 min of treatment. 'Iso. Cont.', isotype control antibody (10 μg/ml). *p < 0.01, relative to the isotype control or medium alone, as determined by a one-way ANOVA with Tukey post-test; n = 2.

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Hall et al. BMC Neuroscience 2008 9:71   doi:10.1186/1471-2202-9-71