Figure 4.

Creatinine levels in plasma (A), creatine levels in brain (B-E), and muscle creatine (F) of animals in Experiment 1 (mean ± SEM expressed as a percent of control). At 7 and 24 h, increases in creatinine were observed in MA-treated animals; at 72 h, a decrease in creatinine was observed in MA-treated animals (A). No differences in brain creatine in MA-treated animals compared to SAL-treated animals were observed in the hippocampus (B), neostriatum (C), prefrontal cortex (D), or cerebellum (E), at any of the time points examined. In addition, no differences were observed between MA-treated and SAL-treated animals in the levels of muscle creatine (F). * p ≤ 0.05 vs SAL.