Gene expression analysis of APP-transgenic mice. A. Northern blot hybridization of total RNA from C3-3 APP-transgenic mouse tissues. Total RNA hybridized with a human APP probe (upper autoradiogram) prior to hybridization with 18S rRNA (lower autoradiogram). B. Gene expression differences among organs obtained from C3-3 mice. The expression of APP genes was normalized by dividing the net intensity of APP bands by the 18S rRNA bands. Different letters above the bars represent statistically significant (P < 0.05) expression levels. B: Brain, H: Heart, K: Kidney, Li: Liver, Lu: Lung.
Agca et al. BMC Neuroscience 2008 9:28 doi:10.1186/1471-2202-9-28