Human APPSw/Ind expression in transgenic rat brain. A. A low power (2×) micrograph demonstrates widespread expression of human APP in the neocortex and hippocampus. Higher power (20×) images show punctate cytoplasmic staining in large cortical pyramidal neurons (B) and hippocampal pyramidal neurons (C). APP staining appears to demarcate the margins of CA2 pyramidal neurons, which were largely devoid of staining (C). Low power (2×) micrograph of an adjacent section stained with an anti-GFAP antibody. GFAP staining reveals the presence of glia and astrocytes within the neocortex and hippocampus (D). Higher power (20×) images from the cortex (E) and hippocampal dentate gyrus (F) are shown for comparison to (B-C) and illustrate that human APPSw/Ind expression in occurring predominately in neurons.
Agca et al. BMC Neuroscience 2008 9:28 doi:10.1186/1471-2202-9-28