Comparison of promoters following lentivirus injection in rat brain. Lentiviruses were stereotaxically injected into rat hippocampus and examined after three months. A. eGFP expression driven by the ubiquitin-C promoter (Ubi-C) was consistently superior to that of other promoters, including the platelet-derived growth factor promoter (PDGF) and cytomegalovirus. Lower panels show representative higher power images of eGFP driven by Ubi-C- (B), cytomegalovirus- (C), and PDGF- (D) promoters in lentivirus/eGFP-injected rats.
Agca et al. BMC Neuroscience 2008 9:28 doi:10.1186/1471-2202-9-28