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Development of transgenic rats producing human β-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically

Cansu Agca1, Jason J Fritz2, Lary C Walker23, Allan I Levey2, Anthony WS Chan3*, James J Lah2* and Yuksel Agca1*

Author Affiliations

1 University of Missouri College of Veterinary Medicine, Department of Veterinary Pathobiology Columbia, MO 65211, USA

2 Department of Neurology and Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA

3 Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA

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BMC Neuroscience 2008, 9:28  doi:10.1186/1471-2202-9-28

Published: 26 February 2008

Additional files

Additional file 1:

Control immunohistochemistry without primary antibody for 6E10 staining. Low power (2×) micrograph demonstrates the lack of non-specific staining in neocortex and hippocampus with biotynalated goat anti-mouse secondary antibody (Vector Laboratories: Burlingame, CA) following no primary negative control for immunohistochemistry with human-specific APP mouse monoclonal antibody 6E10 (Signet; Dedham, MA).

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