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Open Access Research article

The pedunculopontine tegmental nucleus and the nucleus basalis magnocellularis: Do both have a role in sustained attention?

Claire L Rostron1*, Morag J Farquhar2, Mary P Latimer2 and Philip Winn2

Author Affiliations

1 Life Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK

2 School of Psychology, University of St Andrews, St Mary's College, South Street, St Andrews, KY16 9JU, UK

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BMC Neuroscience 2008, 9:16  doi:10.1186/1471-2202-9-16

Published: 30 January 2008

Additional files

Additional file 1:

Sham lesioned animal (bottom right quadrant) in 1500 ms signal duration attention task. The signal light (houselight) is situated on the right of the quadrant and the lever and pellet receptacle on the left of the quadrant. The pellet receptacle is illuminated. The video runs for two trials. The first trial starts with the "dim" light signal that can be perceived as a strip of light along the operant box floor. The presentation of the "bright" signal can be perceived as a flash of light. There is a period of darkness before the second trial begins. In both trials the animal successfully presses the lever during the bright signal. Note: the additional lights that can be seen in the corners of the quadrants are infrared lights.

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Open Data

Additional file 2:

PPTg lesioned animal (top left quadrant) in 1500 ms signal duration attention task. The signal light (houselight) is situated on the right of the quadrant and the lever and pellet receptacle on the left of the quadrant. The pellet receptacle is illuminated. The video runs for five trials to illustrate the full pattern of PPTg lesioned animals' behaviour (correctly performed trials interspersed with omissions). Each trial starts in darkness. The "dim" light signal can be perceived as a strip of light along the operant box floor. The presentation of the "bright" signal can be perceived as a flash of light. In the first and third trial the rat performs correctly, pressing the lever in response to the bright light signal. On the second and fifth trial the rat omits a response due to prolonged sniffing. On the fourth trial the rat omits a response due to prolonged houselight orientation. Note: the additional lights that can be seen in the corners of the quadrants are infrared lights.

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Open Data

Additional file 3:

NbM lesioned animal (bottom right quadrant) in 4000 ms signal duration attention task. The signal light (houselight) is situated on the right of the quadrant and the lever and pellet receptacle on the left of the quadrant. The pellet receptacle is illuminated. The video runs for one trial. The trial starts in darkness. The "dim" light signal can be perceived in the video as a strip of light along the operant box floor. The presentation of the "bright" signal can be perceived as a flash of light. The chosen trial illustrates failed lever pressing where the forepaw is seen extended onto the lever but the bright light has not extinguished. We have chosen the longer signal duration to illustrate the rat attempting to retrieve a food pellet and returning to the lever for additional presses. Note: the additional lights that can be seen in the corners of the quadrants are infrared lights.

Format: MPG Size: 9.9MB Download file

Playing the movie within this page requires QuickTime 6.4 or later and JavaScript. Read more

Open Data