(a) Wild-type mouse spinal cord sections stained for TDP-43 and SMN. Large alpha motor neurons show diffuse cytoplasmic SMN stain and punctate nuclear SMN, Cajal bodies. TDP-43 shows only nuclear and no cytoplasmic staining. (b) Representative merged TDP-43 and SMN stains for all genotypes. Note absence of Cajal bodies in the SMA mouse. The pattern of TDP-43 immunoreactivity is unaltered in SOD1G93A and SMA mice. Scale bar = 20 μm.
Turner et al. BMC Neuroscience 2008 9:104 doi:10.1186/1471-2202-9-104