Neurons are lost throughout embryonic development in Bdnf-/- and Ntf5-/- mice. At E12.5, the geniculate ganglion is still fused with the vestibular-cochlear ganglion, which explains the greater number of neurons in wild type mice at this age. Neurons are lost by E12.5 in Ntf5-/- mice, indicating that NT4/5-dependency begins earlier in embryonic development than does BDNF-dependency. In Bdnf-/- mice, neurons are first lost between E12.5 and E14.5. Losses continue to be greater in these animals, compared to wild type, throughout the remainder of embryonic development.
Krimm BMC Neuroscience 2007 8(Suppl 3):S4 doi:10.1186/1471-2202-8-S3-S4