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The study of nonlocal neural populations involving two neuron types and the effect of propofol

The work derives a neural population model, which considers excitatory and inhibitory synapses as well as excitatory and inhibitory neurons. Then the spatio-temporal dynamics of the neural population is studied subject to the increase of the inhibitory synaptic decay rate. This study is motivated by the effect of the anaesthetic propofol, which increases the inhibitory synaptic decay rate with increased blood concentration and may yield loss of consciousness. We find regimes of stationary multistability and stability criteria for the stationary states. It turns out that the increase and subsequent decrease of propofol yields saddle-node bifurcations in a hysteresis loop.

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Correspondence to Axel Hutt.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hutt, A., Schimansky-Geier, L. & Longtin, A. The study of nonlocal neural populations involving two neuron types and the effect of propofol. BMC Neurosci 8 (Suppl 2), S11 (2007). https://doi.org/10.1186/1471-2202-8-S2-S11

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  • DOI: https://doi.org/10.1186/1471-2202-8-S2-S11

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