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This article is part of the supplement: Sixteenth Annual Computational Neuroscience Meeting: CNS*2007

Open Access Oral presentation

The study of nonlocal neural populations involving two neuron types and the effect of propofol

Axel Hutt1*, Lutz Schimansky-Geier2 and Andre Longtin1

Author Affiliations

1 Department of Physics, University of Ottawa, Ottawa, Ontario, Canada, K1N 6J7

2 Institute of Physics, Humboldt University, Berlin, Germany

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BMC Neuroscience 2007, 8(Suppl 2):S11  doi:10.1186/1471-2202-8-S2-S11

The electronic version of this article is the complete one and can be found online at:

Published:6 July 2007

© 2007 Hutt et al; licensee BioMed Central Ltd.

Oral presentation

The work derives a neural population model, which considers excitatory and inhibitory synapses as well as excitatory and inhibitory neurons. Then the spatio-temporal dynamics of the neural population is studied subject to the increase of the inhibitory synaptic decay rate. This study is motivated by the effect of the anaesthetic propofol, which increases the inhibitory synaptic decay rate with increased blood concentration and may yield loss of consciousness. We find regimes of stationary multistability and stability criteria for the stationary states. It turns out that the increase and subsequent decrease of propofol yields saddle-node bifurcations in a hysteresis loop.