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This article is part of the supplement: Sixteenth Annual Computational Neuroscience Meeting: CNS*2007

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Mechanisms of carbachol oscillations

Theoden I Netoff1*, Lisa Giocomo2 and John A White3

Author Affiliations

1 Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA

2 Program in Neuroscience, Center for Memory and Brain, Boston University, Boston MA, USA

3 Department of Biomedical Engineering, Boston University, Boston MA, USA

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BMC Neuroscience 2007, 8(Suppl 2):P34  doi:10.1186/1471-2202-8-S2-P34

The electronic version of this article is the complete one and can be found online at:

Published:6 July 2007

© 2007 Netoff et al; licensee BioMed Central Ltd.

Poster presentation

Carbachol (CCh) is a cholinergic agonist that causes spontaneous theta frequency oscillations in the entorhinal cortex and hippocampus. To better understand the mechanism by which these oscillations are generated, we measured the effect of CCh on phase response curves from pyramidal neurons and stellate cells in the entorhinal cortex. Based on the measurements, it was predicted that CCh would facilitate synchronization of a network of pyramidal neurons but would have little or even a desynchronizing effect on stellate cells. The pyramidal cell results were then confirmed by coupling pairs of pyramidal neurons using the dynamic clamp and measuring their synchrony in control and CCh conditions.