Table 3

Genes deregulated in both human and animal stroke microarrays

Human

Rat

Human

Rat


Gene name

GenBank

SwissProt

GenBank

SwissProt

Max/min

Days

Max/min

Time


c-jun proto-oncogene

J04111

P05412

X17163

P17325

4.4-fold

9 – 20

3.5-fold

1 h – 24 h

Matrix metalloproteinase 11

X57766

P24347

U46034

P97568

3.2-fold

2 – 20

2.6-fold

3 days

Calcium/calmodulin-dependent kinase (CAMK1)

L41816

Q14012

L24907

Q63450

17.2-fold

2 – 20

0.05-fold

21 days

L26288

Q63084

LIM domain kinase 1

D26309

P53667

D31873

P53669

3.6-fold

2 – 20

2.4-fold

3 days

0.4-fold

21 days

T-Lymphocyte maturation-associated protein

M15800

P21145

U31367

Q64349

1.7-fold

2 – 6

0.2-fold

21 days

Retinoic Acid Receptor beta

M84820

P28702

M81766

P49743

2.0-fold

2 – 6

0.1-fold

21 days

S54072

P28703

Tyrosine Phosphatase 1B

M31724

P18031

M33962

P20417

3.4-fold

2 – 6

0.2-fold

21 days

Adenosine A1 Receptor

S56143

P30542

M64299

P25099

2.6-fold

2 – 6

5.2-fold

4 hrs

Growth arrest & DNA damage-inducible 153

S40706

P35638

U30186

Q62804

2.4-fold

2 – 6

2.1-fold

3 days

S62138

Glutamate Decarboxylase 67

M81883

Q99259

M34445

P18088

5.6-fold

2 – 6

2.5-fold

21 days

Glutamate Decarboxylase 65

M81882

Q99259

M72422

Q05683

22.7-fold

2 – 20

2.2-fold

3 days

Neurotrophin 3

M37763

P20783

M34643

P18280

5.1-fold

2 – 37

2.2-fold

12 hrs

Inhibitor of DNA binding 2

M97796

Q02363

D10863

P41137

5.6-fold

2 – 20

0.4-fold

21 days

Neuropeptide Y

K01911

P01303

M20373

P07808

8.8-fold

2 – 20

0.04-fold

21 days

Glia Maturation Factor beta

M86492

P17774

Z11558

Q63228

7.6-fold

2 – 6

0.04-fold

21 days

High Mobility Group Protein 1

M23619

P17096

M64986

P27109

4.3-fold

2 – 37

3-fold

4 h – 3 d

P27428

0.3-fold

21 days

Early Growth Response Protein 1

X52541

P18146

M18416

P08154

4.4-fold

2 – 20

3.9-fold

1 h – 12 h

M62829

J04154

0.2-fold

21 days

TAT-Binding Protein 1

M34079

P17980

U77918

P97638

3.8-fold

2 – 20

0.4-fold

21 days

Glutathione S-Transferase 1

J03746

P10620

J03752

P08011

17.5-fold

2 – 20

10.8-fold

24 h – 21 d

Fibroblast Growth Factor Receptor 1

M63887

Q02063

D12498

Q04589

10.1-fold

2 – 20

4-fold

4 h – 24 h

M63888

Q02065

M63889

Interleukin 10

M57627

P22301

L02926

P29456

2.4-fold

2 – 20 26 – 37

6.4-fold

21 days

Q63263

0.2-fold

Heat Shock Protein 27

X54079

P04792

M86389

P42930

0.6-fold

2 – 20

15.2-fold

4 h – 24 h

Heat Shock Protein 70

M11717

P08107

Z27118

Q63718

0.6-fold

2 – 6

9.4-fold

1 h – 24 h

P19790

Thioredoxin Peroxidase 1

L19185

P32119

U06099

P35704

4.9-fold

2 – 20

3.9-fold

21 days

X82321

P31945

Platelet-Derived Growth Factor A

X06374

P04085

L06894

P28576

1.6-fold

2 – 6

0.5-fold

21 days

Matrix Metalloproteinase 14

X83535

Q92678

X83537

Q10739

6.9-fold

2 – 6

3.3-fold

24 h – 3 d

Kinase receptor TYRO3 Sky proto-oncogene

D17517

Q06418

D37880

P55146

3.1-fold

9 – 20

4.0-fold

24 h – 3 d

0.4-fold

21 days

CSF-1-Receptor

X03663

P07333

X61479

Q00495

89.2-fold

9 – 20

2.8-fold

3 days

Insulin-like Growth Factor Binding Protein 2

M35410

P18065

J04486

P12843

79.7-fold

9 – 20

2.1-fold

3 days

Mitogen activated kinase 1/2

M84489

P28482

M64300

P27703

48.6-fold

9 – 20

0.3-fold

21 days

Aquaporin 4

U34846

P55087

U14007

P47863

18-fold

9 – 20

3.2-fold

3 days

erbB2 proto-oncogene Neu proto-oncogene

M95667

P04626

X03362

P06494

11.2-fold

9 – 20

2.7-fold

12 hrs

M11730

Q14256

L-type calcium channel β3

U07139

P54284

M88751

P54287

10.3-fold

9 – 20

8.6-fold

21 days

Ras-related protein RAB3A

M28210

P20336

X06889

P05713

13.9-fold

9 – 20

0.3-fold

21 days

CAMK-II beta

U50358

Q13554

M16112

P08413

1.8-fold

9 – 20

0.3-fold

21 days

Growth Factor Receptor-Bound 2

L29511

Q63057

D49846

Q63057

19.9-fold

9 – 20

2.7-fold

3 days

M96995

Q14450

Q14450

Signal Transducer & Activator of Transcription 3

L29277

P40763

X91810

P52631

0.4-fold

9 – 20

6.6-fold

4 h – 3 d

0.05-fold

21 days

Neuronatin

U25033

Q16517

U08290

Q62649

11.1-fold

9 – 20

0.4-fold

21 days

Q62663

Glutathione S-Transferase P

X08058

P09211

X02904

P04906

3.1-fold

9 – 20

0.1-fold

1 hr

Glucocorticoid-regulated serine/threonine kinase GSK

AJ000512

O00141

L01624

Q06226

0.6-fold

26 – 37

2.4-fold

3 days

0.05-fold

21 days

Glucose Transporter 1

K03195

P11166

M13979

P11167

0.6-fold

26 – 37

11.6-fold

4 h – 21 d


Mitsios et al. BMC Neuroscience 2007 8:93   doi:10.1186/1471-2202-8-93

Open Data