Sensory motor and spatial learning ability measured in the water maze. 1A shows the latency to escape to the visible escape platform during cue training. There are no differences in the performance of any of the groups. 1B shows the search error during the acquisition of the spatial reference memory task. The 2-week R-flurbiprofen-treated mice (Therapeutic group) performed more poorly than the other groups (Preventative group) on days 4, 7, 8, 9 and 10. 1C shows that only the Tg2576 mice treated for 16 weeks (Preventative group) with R-flurbiprofen developed a spatial bias for the training quadrant. 1D shows representative swim paths of the Control and the Preventative groups during Probe Trial 3. Note that the R-flurbiprofen-treated mice focus their search in the training quadrant that contained the hidden escape platform (bottom left quadrant). 1E shows the percent of subjects that preferred using a cue or place strategy during the strategy competition. 80% of the Tg2576 mice in the Preventative group preferred using a place strategy compared to only 30% of the Control and 31% of the Therapeutic group (Chi-square = 11.23, p < .01).
Kukar et al. BMC Neuroscience 2007 8:54 doi:10.1186/1471-2202-8-54