Neurite branching. Construction and stability of the microtubule cytoskeleton may determine both elongation and branching rates. Microtubule bundles are cross-linked by microtubule-associated proteins, such as MAP2. Dephosphorylated MAP2 stabilises the bundles and promotes microtubule assembly, and hence elongation. Phosphorylated MAP2 loses its cross-linking ability, destabilising the bundles and thus increasing the likelihood of neurite branching.
Graham and van Ooyen BMC Neuroscience 2006 7(Suppl 1):S9 doi:10.1186/1471-2202-7-S1-S9