Table 1

A list of major pre-synaptic proteins in the mammalian synapse.

Protein

ID UniProt

Symbol HUGOa

Localization

TMD

Commentb


1. Amisyn

Q8NFX7

STXBP6

Cyt

No

Exo

2. Amphyphysin

P49418

AMPH

SV, PM

No

Endo

3. Basoon

Q9UPA5

BSN

Cyt

No

M

4. Bridging integrator

O00499

BIN1

Cyt, SV

No

M*

5. CAPS

Q9ULU8

CADPS

Cyt, SV

No

Exo

6. CASK

O14936

CASK

Cyt

No

M. Exo

7. CASKIN

Q8WXD9

CASKIN1

Cyt, PM

No

M. Exo

8. CAST

O15083

CAST1

Cyt, PM

No

M

9. Complexin

Q6PUV4

CPLX2

PM

No

Exo

10. CSP

Q9H3Z4

DNAJC5

Cyt, SV

No

M, Exo

11. Doc2

DOC2A

Q14183

SV

No

Exo

12. Dynamin

P50570

DNM2

Cyt, SV

No

M, Endo

13. Epsin

Q9Y6I3

EPN1

Cyt

No

M, Endo

14. Hrs-2

O14964

HGS

Cyt, SV

No

M

15. Intersectin

Q15811

ITSN1

CytSV

NoNo

Endo, M

16. Latrophilin

O94910

LPHN1

PM

Yes

Exo

17. Liprin-α

Q13136

PPFIA1

Cyt

No

M*

18. Mint/X -11

Q02410

APBA1

Cyt

No

M, Exo

19. Munc-13

Q9UPW8

UNC13A

Cyt, PM

No

M, Exo -Endo

20. Munc-18

O00186

STXBP3

Cyt, PM

No

Exo

21. Neurexin

P58400

NRX1

PM

Yes

M, Exo

22. NSF

NSF

P46459

SV, Cyt

No

M*

23. NT transporter

P23975

SLC6A2

SVPM

Yes

M

24. NTvesicle transporter

Q16572

SLC18A3

PMSV

Yes

M

25. P/Q Ca2+ channel

O00555

CACNA1A

PM

Yes

Exo

26. Pallklin

Q9UL45

PLDN

Cyt, SV

No

M

27. Piccolo

Q9Y6VO

PCLO

Cyt

No

M

28. Rab3

P20336

RAB3A

Cyt, SV

No

M, Exo *

29. Rabconnectin-3

Q8WTV7

DMXL2

Cyt

No

M, Exo

30. Rabphilin

Q9Y2JO

RPH3A

SV

No

M, Exo

31. RIM

Q86UR5

RIMS1

PM

No

M, Exo

32. RIMS binding protein

O15034

RIMBP2

SV

Yes

Exo, M *

33. SCAMP

O15126

SCAMP1

SV

Yes

M

34. SNAP-25

P60880

SNAP25

PM

No

Exo

35. Snapin

O95295

SNAPAP

PM, Cyt

No

Exo, Endo

36. Stonin-2

Q8WXE9

STN2

Cyt

No

Endo

37. SV2

Q7L0J3

SV2A

SV

Yes

Exo, M

38. Synapsin

P17600

SYN1

SV

No

M

39. synaptogyrin

O43759

SYNGR1

SV

Yes

Exo

40. Synaptojanin

O43426

SYNJ1

Cyt PM

No

Endo*

41. Synaptophysin

P08247

SYP

SV

Yes

M, Exo

42. Synaptotagmin

P21579

SYT1

SV

Yes

Exo, Endo

43. Syntaphilin

O15079

SNPH

PM

Yes

Exo

44. Syntaptoporin

Q8TBG9

SYNPR

PM

Yes

Exo

45. Syntaxin

Q16623

STX1A

PM

Yes

Exo

46. Tomosyn

Q5T5C0

STXBP5

PM

Yes

Exo

47. VAMP

P63027

VAMP1

SV

Yes

Exo

48. VAT-1

Q99536

VAT1

SV

No

M

49. Vo

P27449

ATP6V0C

PM

Yes

Exo, Endo

50. α-SNAP

P54920

NAPA

SV

No

M, Exo


Most proteins that function in the mammalian SV life cycle are listed. aProtein symbols are provided by HUGO, the Human Genome Organization Gene nomenclature committee http://www.gene.ucl.ac.uk/nomenclature/ webcite. IDs are according to UniProt database http://www.expasy.uniprot.org webcite. bProteins listed are from Human are marked according to their main function in exocytosis (Exo), endocytosis (Endo) and synapse maintenance (M). The proteins with intrinsic enzymatic activity are marked by an asterisk (*). Proteins whose function is in building, shaping and maintenance of the pre-and postsynaptic structures are not included. For simplicity only one representative of a gene family is listed. PM, plasma membrane; Cyt, cytosol; TMD, transmembrane domain.

Brachya et al. BMC Neuroscience 2006 7(Suppl 1):S4   doi:10.1186/1471-2202-7-S1-S4

Open Data