TOG contains multiple hnRNP A2 binding sites. The TOG protein is depicted in cyan with identified HEAT repeats in red and an NTF2 homology domain in yellow. hnRNP A2 dimers ar shown in light blue. Seven subfragments of TOG protein were cloned, each corresponding to a cluster of HEAT repeats or alpha helical domains. Each subfragment of TOG showed binding to hnRNP A2. Binding to TOG subfragments caused dissociation of hnRNP A2 oligomers to dimers.
Carson et al. BMC Neuroscience 2006 7(Suppl 1):S3 doi:10.1186/1471-2202-7-S1-S3