A molecular model of neuronal apoptosis organized in submodules. The central part of the model (green panel) represents the mitochondria submodule and all the molecules that regulate its function as "sensor" of the cellular stress responses (yellow panel). Dark blue and green arrows indicate survival and apoptotic pathways, respectively; orange arrows indicate inhibitions. Red arrows indicate the positive feed-back, while in purple and light blue are indicated the cross-talk between extrinsic/intrinsic apoptotic cascades and the survival regulatory control by IAPs, respectively. More information is the text.
Alberghina and Colangelo BMC Neuroscience 2006 7(Suppl 1):S2 doi:10.1186/1471-2202-7-S1-S2