Table 2

Effects of NE-100, (+)-MK-801 and of a co-treatment of raclopride with clozapine in enriched hippocampal neuronal cultures, as estimated by the MTT and NR assays

Drugs

MTT (% of control)

NR (% of control)


Control

100 ± 6

ND

+ N2

177 ± 10

ND

+ Raclopride (10-6 M)

103 ± 5

ND

+ Clozapine (10-6 M)

199 ± 13

ND

+ Raclopride (10-6 M) + Clozapine (10-6 M)

117 ± 8

ND

Control

100 ± 6

100 ± 4

+ NE-100 (10-7 M)

97 ± 6

93 ± 3

+ NE-100 (10-6 M)

112 ± 9

95 ± 4

+ NE-100 (10-5 M)

127 ± 9

82 ± 5*

Control

100 ± 5

100 ± 8

+ (+)-MK-801 (10-6 M)

123 ± 9

128 ± 6

+ (+)-MK-801 (10-5 M)

130 ± 12

112 ± 14


Data represent mean ± SEM of at least three separate experiments. *p < 0.01, control versus drugs-treated cells. p < 0.01, cells treated with clozapine alone versus cells co-treated with raclopride and clozapine. ND: not determined.

Bastianetto et al. BMC Neuroscience 2006 7:28   doi:10.1186/1471-2202-7-28

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