Parkin deficient-mice are not more sensitive to 6-OHDA toxicity. A. WT mice (filled square symbols) and KO mice (open circle symbols) treated with 4 μg 6-OHDA or 8 μg 6-OHDA displayed similar contralateral, rotational behavior (expressed as net negative rotations) following APO-treatment. B. Ipsilateral rotational behavior (expressed as net positive rotations) following AMPH treatment was also indistinguishable between WT and KO mice. C. There was no difference between WT and KO mice in striatal dopamine (DA) levels (expressed as ng/mg protein) on the intact, uninjected side versus the side treated with SAL, 4 μg 6-OHDA, or 8 μg 6-OHDA. The numbers of mice used for each genotype are indicated in A; these same mice were also analyzed in B and C. Data are expressed as mean ± SEM.
Perez et al. BMC Neuroscience 2005 6:71 doi:10.1186/1471-2202-6-71