Progression of axon degeneration in shape of a continuous degeneration gradient appears roughly synchronous along individual WldS axons A-H: Graphs showing the number of axonal constrictions and breaks along individual YFP labelled WldS axons with an anterograde gradient of degeneration in relation to the distance in mm from the transection point 15 days (A, B) and 20 days (C, D) after transection lesion or from the crush point 15 days (E, F) and 20 days (G, H) after crush lesion. Means and standard deviations are presented in B, D, F, H. Note that with increasing distance from the transection and crush point degeneration signs decrease uniformly characterized by the steady decline of the curves. Moreover, degeneration in different WldS fibres is broadly synchronous as shown by the good superimposition of individual curves in A, C, E, G.
Beirowski et al. BMC Neuroscience 2005 6:6 doi:10.1186/1471-2202-6-6