Figure 6.

Model of parkin directed ubiquitination of α-synuclein. The parkin protein consists of two functionally distinct regions. The UBL/UPD region binds target proteins such as glycosylated α-synuclein. The RING-box (RING1-IBR-RING2) region recruits specific E2 ubiquitin conjugating enzymes, which add ubiquitin monomers to the target protein. In addition to substrate binding the UBL domain interacts with the proteasome. Ubiquitin tagged α-synuclein is directed to the proteasome and degraded into polypeptides and ubiquitin monomers. UBL –
    Ub
iquitin-
    l
ike Domain, UPD –
    U
nique
    P
arkin
    D
omain, RING1 or 2 –
    R
eally
    I
nteresting
    N
ew
    G
ene finger 1 or 2 domain, IBR –
    I
n-
    B
etween
    R
ing domain.

Haywood and Staveley BMC Neuroscience 2004 5:14   doi:10.1186/1471-2202-5-14
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