The expression of BDNF and NT-3 mRNA is shown in the P0 vestibular sensory epithelia. Silver grains are false colored as red to enhance visibility against the grey Nissl-stained background. Canal cristae contain only BDNF (a,b), but gravistatic endorgans, such as saccule and utricle, contain both BDNF and NT-3 (c-f). Note the prominent BDNF expression in the hair cell region (HaC) of control canal (b) and saccule (d) and low levels of expression in the Brn3c null mice (a,c) over immature hair cells (iHC). The NT-3 expression is much more diffuse in both control and Brn3c mutant littermates. Bar indicates 100 μm.
Xiang et al. BMC Neuroscience 2003 4:2 doi:10.1186/1471-2202-4-2