Decreasing AGRP levels with siRNA increases metabolic rate. (a) Heat production for AGRP-siRNA injected mice was found to be significantly and dramatically elevated one day following surgery compared to the control injected GFP-siRNA mice (n = 16; p < 0.0001). (b) Oxygen consumption, VO2, was also significantly elevated one day after surgery for mice injected with the AGRP-siRNA particles (n = 16; p < 0.0003).
Makimura et al. BMC Neuroscience 2002 3:18 doi:10.1186/1471-2202-3-18